Endocrine Disruptors

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An endocrine disruptor is an exogenous substance or mixture that alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism, or its progeny, or (sub)populations (EC).

Endocrine disrupting chemicals are mostly man-made substances that can mimic or interfere with the function of hormones in the body. Endocrine disruptors can interfere i.e. turn on, turn off, or modify hormone-transmitting signals that can affect normal tissue and organ functions. Many of these substances have been associated with developmental, reproductive, neural, immune and other problems animals or men. Endocrine disruption is a specific form of toxicity, where natural and/or anthropogenic chemicals, known as endocrine disruptors, trigger adverse health effects by disrupting the endogenous hormone system.

The endocrine disruptors are assessed and tested according to OECD Conceptual Framework, which was introduced by the EDTA (OECD Endocrine Disrupter Testing and Assessment Task Force) in 2002. 

The Concept specifies five different investigation levels for the risk assessment of endocrine disrupting chemicals. The main pathways addressed are Oestrogen, Androgen, Thyroid and Steroidogenesis.

Level 1: Sorting & prioritization based upon existing information

Level 2: In vitro assays providing mechanistic data

Level 3: In vivo assays providing data about single endocrine Mechanisms and effects

Level 4: In vivo assays providing data about multiple endocrine Mechanisms and effects

Level 5: In vivo assays providing data on effects from endocrine & other mechanisms

For interpreting the outcome of individual tests and compiling evidence on whether or not a substance may be an endocrine disrupter OECD Guidance Document No. 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption is applied.

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InterBioTox is prepared to support you in testing your substance on endocrine disrupting properties with the following studies/services:

Analytical Chemistry

InterBioTox fully supports selected ecotoxicology and in vivo toxicology studies within a safety assessment of endocrine disruptors using a comprehensive GLP analytical services. Choose the study...


InterBioTox offers the aquatic, sediment and terrestrial ecotoxicology studies on endocrine disruptors for the environmental safety assessment within Level 4 of the Conceptual Framework in GLP quality (the offered studies are OECD 234, 218, 219, 211, 222 and 225). Choose the study...

In vitro Toxicology

InterBioTox provides an in vitro assay in GLP quality on Estrogen or androgen receptor binding affinity (YES/YAS Assay) within Level 2 of the OECD Conceptual Framework. Choose the study...

In vivo Toxicology

Mammalian in vivo toxicology studies on endocrine disruptors  play an important part within safety assessment of these products. InterBioTox supports the clients with the GLP studies in Level 4 of the OECD Conceptual Framework: sub-acute (OECD 407), sub-chronic & chronic (OECD 408 and 453), and reproductive & developmental toxicology studies (OECD 414, 416, 421 and 422). Choose the study...


InterBioTox fully supports the in vivo toxicology studies within Level 4 of the OECD Conceptual Framework by conduct of histopathology as a requisite part of the mammalian toxicology studies and fully pursuant to the latest guideline. Choose the study...


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