Cosmetic products are defined according to the European Directive 76/768/EEC as any substance or mixture intended to be placed in contact with external parts of the human body (epidermis, hair system, nails, lips and external genital organs) or with the teeth and the mucous membranes of the oral cavity, with a view exclusively or mainly to cleaning them, perfuming them, changing their appearance, protecting them, keeping them in good condition or correcting body odours. Cosmetic products shall be safe for human health under normal or reasonably foreseeable conditions of use.
According to Regulation 1223/2009 on cosmetic products, since 2013 it has been banned to carry out experiments on animals to evaluate the safety and efficacy of cosmetic products or their components. The testing in vivo on cosmetics has been replaced by in vitro testing. In vitro testing uses a versatile, sophisticated and cost-effective testing methods and is an excellent alternative to animal testing for long time.
To be able to carry out trials in vitro, the OECD and ECVAM have already validated a set of tests that respond to the needs of evaluators.
To ensure the safety of the product for human use, the InterBioTox offers different studies to verify the human and environmental safety and toxicity of the cosmetics.
The recent aim of manufacturer in the cosmetic industry is to produce cosmetics products as much environmentally friendly as possible. Ecolabelled cosmetic products are among the least environmentally hazardous products within their category and they fulfil both environmental and health related requirements. One of the key indicator is the biodegradation of active ingredients within the cosmetics products. InterBioTox provides well established standardized methods to assess the ready and inherent biodegradability in the relevant environmental conditions. The OECD 301 method for ready biodegradability in water is a reliable method that is often used for cosmetic ingredients and that the regulative authority is currently considering as a reference. Choose the study...
Many cosmetics brands and manufacturers in the cosmetics industry use in vitro models to ensure the regulatory safety and toxicity testing of cosmetics and ingredients, as well as to test efficacy, support product claims, and confirm the listed ingredientsInterBioTox provides you with alternative methods to animal experiments and offer you a wide spectrum of the studies and tests according to the principles of Good Laboratory Practice (GLP) like in vitro Skin Corrosion and Irritation, in vitro Eye Irritation, in vitro Sensitisation, skin and ocular tolerance testing, phototoxicity testing etc.
A special part represents in vitro Mutagenicity (OECD 471) and In vitro Genotoxicity (OECD 487) acc. to recommendation of Revision of the Addendum to the SCC`s Notes of Guidance (NoG) for the Testing of Cosmetic Ingredients, 2014). Choose the study...
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