We are proud to house a family of innovative members.
After adding new areas of work, in 2002 we received the GLP certification in 6 different categories: category 1 (Physico-chemical parameters), 3 (in vitro - Toxicology), 4 (Ecotoxicology), 5 (Environmental Fate), 6 (Residue Studies) and 8 (Analytics on Biological Materials).
The Centre of Experimental Medicine (CEM) of the Slovak Academy of Sciences (SAS) was established by merging of the Institute of Experimental Pharmacology and Toxicology, the Institute of Normal and Pathological Physiology and the Institute of Heart Research into one Centre. CEM is focused on the integrated research into the causes, mechanisms of development and possibilities of prevention, diagnosis and treatment of societally important diseases with the emphasis on diseases of the cardiovascular and the nervous systems, metabolic disorders, mental disorders and mental health problems as well as diseases originating in the prenatal and early postnatal developmental periods. The research in CEM is carried out on in silico, in vitro, ex vivoain vivo models with the aim to transfer the acquired knowledge to clinical practice.
An important part is the evaluation of the effects of bioactive natural substances, their derivatives and original synthetic substances with pharmacotherapeutic potential, on animal models of human diseases and human samples, as well as the study of side effects and toxic effects of chemicals and radiation.
The facilty has been GLP recertified in 2019 ad has an expertise for many regulatory in vivo acute, semichronic and chronic toxicological and safety studies with a special part to reproductive & development studies on rats and rabbits. The GLP certifctaion also includes a state-of-the art in vitro toxiclogy lab for determination of adverse effects of test items to skin, eye and other tissues in vitro.
- Medical industry incl. medical devices
- Chemical substances and preparations
- New materials
- Industrial biotechnologies (manufacture of products based on enzymes and microorganisms to be used further in chemical industry, healthcare, manufacture of food products and feeds, washing agents, paper and cellulose, textiles, as well bioenergetics)
The PharmValley represents full-cycle activities (development, preclinical and clinical studies, preparation of a registration dossier and registration, synthesis of pharmaceutical substances, development of a finished dosage form) and services necessary for manufacture of drugs and medical devices for pharmaceutical industry in accordance with international standards of the good practices (GLP, GCP and GMP). A special part represents research and studies on primates, at the unique center primatology center in Russia, which is one of the largest in Europe. Preclinical toxicological and safety studies of biomedical drugs, chemical substances and preparations (REACH) and other products on SPF laboratory animals (mice, rats, hamsters), incl. investigation of their pharmacological action and effects are fully performed in compliance with the international GLP standards.
Sitno Pharma, Ltd. is member of the Holding Group called Sitno Holding a.s., group of the companies offering Investment Consulting Services, Searching for strategic partners for investment-intensive projects and Crisis Management.
Her aim is to integrate and to offer to clients the R&D and pharmaceutical production capacities of our partners in effective scientific cooperation in the fields of chemical sciences, bioinformatics and chemical engineering, industrial biotechnology, pharmaceutical chemistry, pharmacology and toxicology.